Updating the rna polymerase ctd code
Transcription of genomic regions in eukaryotes is a complex phenomenon generating a variety of RNAs, only a subset of which is derived from protein coding genes (m RNAs).The non-coding transcriptome includes numerous RNA species involved in the regulation of translation (t RNAs and r RNAs), but more recent studies have indicated the presence of several types of RNA molecules that have the potential to regulate gene expression [A).A highly positioned 1 nucleosome covering the transcription start site (→) directs precise positioning of nearby nucleosomes, but its influence wanes with increasing distance from the TSS.The presence of nucleosomes over coding regions masks the cryptic promoter elements found throughout the genome and thus prevents aberrant transcription initiation.
We review the molecular mechanisms involved in the suppression of these cryptic initiation events and discuss the role played by nc RNAs in regulating gene expression.Bonnart C, Gérus M, Hoareau-Aveilla C, Kiss T, Caizergues-Ferrer M, Henry Y, Henras AK. Boulon, S., Marmier-Gourrier, N., Pradet-Balade, B., Wurth, L., Verheggen, C., Jády, B. C., Kiss, T., Bardoni, B., Krol, A., Branlant, C., Allmang, C., Bertrand, E., and Charpentier, B. (2012) Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication. (2008) The HSP90 chaperone controls the biogenesis of L7Ae RNPs through a conserved machinery. Chauvin C, Koka V, Nouschi A, Mieulet V, Hoareau-Aveilla C, Dreazen A, Cagnard N, Carpentier W, Kiss T, Meyuhas O, Pende M. (2014) Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.