Sedating children for mri

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Only one capsule out of 20 contained just over 10% of powder fill (112%) and the rest were within an acceptable range (±10%).

sedating children for mri-44

There were no other appreciable airway or breathing effects.Natural sleep is an attractive option provided it is predictable and reliable, but at present, it is practical only in small infants who sleep after a feed.1Melatonin, a hormone involved in the diurnal rhythm of sleep, is a potentially useful oral natural-sleep agent2,3 and is available commercially.It is classed as a ‘dietary supplement’ by the United States Food and Drug Administration. using a validated paediatric sedation observational scale11 with minor modification (Table 1).Uncooperative children requiring routine MRI (less than 60 min in duration) were recruited if they were suitable for sedation and if their body weight was between 5 and 40 kg. In the pilot study, children weighing , maximum dose 5 mg). Children were considered recovered and ready for discharge only after they could respond easily to command and if they could eat or drink normally: this corresponded to sedation level 1 or 2. Children less than 15 kg received melatonin 3 mg and those who were heavier received 6 mg. We anticipated that even though some children would reach sedation level 3, they could rouse later and require further sedation drugs: these events were recorded but not used as the primary outcome.All children were observed for at least 2 h after scanning. Sedation level was recorded every 5 min for the first 30 min after the administration of melatonin, and every 10 min thereafter. Secondary outcome measures included the time to fall asleep (quiet, not moving and eyes closed), the requirement for further top-up sedation, the scan success rate and, after scanning, the time taken to achieve criteria for discharge.

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